OPE Journal

37 Magazine for Organic & Printed Electronics Manufacturing paper-based electrochemical biosensors IMPETUS is a new pilot line dedicated to quantitative biosensing in liquids There is an increasing demand in medical diagnostics for inexpensive, fast, easy-to-use and quantitative systems for the detection of biomolecules. These systems are intended to close the gap between the currently available non-quantitative tests (e.g. simple colour test strips) and complex analyses in special laboratories. The Horizon 2020 IMPETUS project combines paper, printing and microchip technologies to realise a pilot line in an industrial envi- ronment capable of manufacturing fully integrated paper-based electrochemical biosensors that directly transfer the meas- ured data to the user’s smartphone. These biosensors will be designed as self-powered disposable test cards (standard credit card size) that combine the simplicity of lateral flow tests with quantitative readout, which is enabled by the implemented electrochemi- cal detection method. As an application example, IMPETUS will fulfil the consumer need for fast and inexpensive point-of-care discrimination between bacterial and viral infections. New technologies for paper manufacturing, coating and surface modification The IMPETUS goals will be achieved by developing new technologies for paper manufacturing, coating and surface modi- fication, and the respective processing is working hand in hand with the ink develop- ment (cellulose-based inks for fabricating the printed battery as well as bio-inks for surface functionalisation and reagent deposition). A highly integrated and energy efficient silicon microchip is developed that enables elec- trochemical signal acquisition, storage and contactless NFC transmission. The microchip will be mounted onto the paper substrate by an inline placement process. Paper is employed as substrate for the printed circuits and the microchip, but also as active compo- nent of the printed battery as well as of the biosensor. The IMPETUS pilot line set-up at tagtron GmbH will integrate screen-, flexo-, inkjet-printing and an unhoused chip place- ment in a seamless roll-to-roll process com- patible with high throughput fabrication. As result, the pilot line will offer the possibility to be easily adapted for various sensing applications (e.g. medical diagnostics, food safety) accessible to interested third parties after the project end. Coordinated by AIT IMPETUS is a four-year collaborative project, which has received funding from the European Union’s Horizon 2020 research and innovation programme (topic H2020-PILOTS-05-2017 Paper-based electronics) under grant agree- ment No 761167 and is coordinated by Dr Rainer Hainberger of the AIT Austrian Insti - tute of Technology GmbH. The project has been launched in January 2018 and brings together fourteen leading partners with a strong focus on industrialisation: four research institutes (AIT Austrian Institute of Technology GmbH, Silicon Austria Labs GmbH, Papiertechnische Stiftung, Technische Universität Chemnitz), five small-medium (Maurer Services GmbH, Maurer Engineering UG, Pro-Active sprl, Saralon GmbH, tagtron GmbH) and five large enterprises (Felix Schoeller Holding GmbH & Co KG, Infineon Technologies Austria AG, R-Biopharm AG, Ricoh UK Products Ltd, Sun Chemical Ltd). In summary, the IMPETUS pilot line will pave the way towards the real-world application of paper-based quantitative electrochemical diagnostic test cards, thereby clearly advanc- ing the current state-of-the-art, which up to now has mostly focused on individual fabrica- tion processes and device concepts. Image sources: pmTUC, TU Chemnitz & tagtron GmbH Fig. 1: The self-powered disposable IMPETUS biosensing cards are designed in the size of a standard credit card. Fig. 2: The IMPETUS pilot line set-up at tagtron GmbH will integrate screen-, flexo-, inkjet- printing and an unhoused chip placement in a seamless roll-to-roll process.